Celebrex :  Essential information
 

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Dosage

Contraindications

Precautions

Side effects

Drug interactions

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Dosage recommended:

Osteoarthritis:

100mg oral twice a day or 200mg daily

Rheumatoid arthritis:

200mg once or twice a day

Contraindications

Allergy to sulphonamide
Severe anaphylactic allergy reactions to known non steroidal anti-inflammatory drugs
Asthma precipitated by known non steroidal anti-inflammatory drugs
Pregnancy

Precautions

Allergy to other non steroidal anti-inflammatory drugs
Asthma
Known severe renal insufficiency
Known liver disease
Heart failure
Uncontrolled hypertension
Fluid retention
Known previous peptic ulcer, or haemorrhage, especially in the elderly

Side effects

Allergies - rashes, urticaria, rarely anaphylaxis
Cardiovascular - Fluid retention, aggravated hypertension, and heart failure
Gastrointestinal - Abdominal pain, flatulence, nausea, diarrhoea, peptic ulcers, gastrointestinal bleed. (Ulcer and bleeding may occur from other causes than anti-inflammatories. Studies show no increase in serious side effects compared to placebo)
Neurological - Dizziness, headache, insomnia

Drug interactions

Caution required with warfarin, especially on initiation. Trials showed no change in the INR with celecoxib.
No interaction with methotrexate
Interaction is noted with:
Lithium - levels rise with celecoxib use
Fluconazole - increased blood levels of celecoxib is noted with fluconazole
Aspirin - can be used with celecoxib, but increases risk of peptic ulceration

 

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